作者登录
1.个人简介
Kamel Meguellati，男，教授，博士，博士生导师。曾在法国斯特拉斯堡大学 ISIS研究所攻读博士学位，师从诺贝尔奖得主 Jean-Marie Lehn 教授（1987年诺贝尔化学奖）、Martin Karplus 教授（2013年诺贝尔化学奖）以及Sylvain Ladame博士。在攻读博士期间，他参与了动态共价组合化学（DCC）系统在生物中的应用研究，并与Karplus教授团队合作开发染料-分子动力学预测工具。博士毕业后，Meguellati教授赴美国斯克里普斯研究所从事博士后研究，师从世界著名天然产物全合成大师 K.C. Nicolaou 教授，参与Maitotoxin、Rhizopodin等高复杂性天然产物的全合成工作。之后，他加入美国西北大学（Northwestern University），在Bartosz Grzybowski 教授课题组任职，领导开发了全球首个人工智能化学逆合成平台——Chematica（现商品名为Synthia），并作为核心贡献者之一推动了该平台的应用落地。在工业界，Meguellati教授先后在瑞士先正达（Syngenta）、法国Adocia公司、诺华制药（Novartis）等国际知名企业任研究员，参与开发抗癌药物、糖尿病治疗新分子、绿色杀虫剂等多项具有产业化前景的项目，具备深厚的技术转化经验。在进入点点手机版app之前，Meguellati教授曾任教于吉林大学生命科学学院，作为教授兼博士生导师，他带领团队深入开展人工生物系统、核酸结构靶向小分子及不对称合成反应等研究，取得了诸多原创性成果，指导多位研究生走向国际科研前沿。目前，Kamel Meguellati 教授已在包括《Angewandte Chemie》、《ACS Catalysis》、《Organic Letters》、《Advanced Functional Materials》、《Physical Review Letters》等在内的国际高水平期刊上发表70余篇论文，并拥有多项国际专利。
2.讲授课程
《人工智能（AI）在科学研究中的原理与应用》国际学院
3.研究方向
（1） 量子合成基因组学与结构表观遗传学
基于量子材料与量子计算的基因调控新机制；
构建新型合成基因，用于癌症和代谢病治疗；
研究染色质三维结构、DNA二级结构（如G-四链体、i-motif等）与表观遗传修饰之间的耦合关系。
（2） 人工智能辅助药物设计（AIDD）
基于深度学习、图神经网络与量子计算的靶点发现与分子优化；
自主开发AI平台SciLearnia，融合大数据与预测建模用于精准药物开发；
跨越从“虚拟筛选”到“智能合成路径规划”的全过程药物研发策略。
（3） 高级DNA结合物与复杂天然产物全合成
全合成高结构复杂性天然产物；
合成DNA结构专一性结合小分子，实现精准调控基因表达；
创新G4/i-motif结合药物分子的设计策略，开发新型癌症治疗分子工具。
4.学生培养与合作机会
（1）点点手机版app大学生创新创业训练计划项目申报
（2）高水平国际合作平台：与美国斯克里普斯研究所、牛津大学、新加坡国立大学、哥伦比亚大学、北大、清华、复旦等多所世界顶级高校和研究机构保持长期合作
（3）交叉学科技能培养：学习AI算法、Python/R编程、3D分子建模、文献挖掘与科研写作等技能
（4）高产出科研平台：平均每位研究生可参与8–10篇高水平论文的发表
（5）职业发展助力：多位毕业生升入世界一流高校或科研机构深造，如斯克里普斯研究所、牛津大学、纽约大学、NUS等。
5.代表性论文和专著
[1] Muhammad Siddique Ahmad, Bing Zeng, Ruqiya Qasim, Dehui Zheng, Qing Zhang, Yi Jin, Qifeng Wang,Kamel Meguellati, Ni-Catalyzed Cyanation of (Hetero)aryl Halides with Acetonitrile as Cyano Source, ACS Catalysis, 2024, 14(4):2350-2357,
https://doi.org/10.1021/acscatal.3c05836
[2] Nuraddeen Bello Ahmad, Mohammed Sani Jaafaru, Zaharaddeen Isa, Yusuf Abdulhamid Rahanatu Adamu Kakudi, Adamu Yunusa Ugya, Kamel Meguellati, High pollution loads engineer oxygen dynamics, ecological niches, and pathogenicity shifts in freshwater environments, Journal of Hazardous Materials Advances, 2024, 14, 2024, 100425,
https://doi.org/10.1016/j.hazadv.2024.100425
[3] Muhammad Siddique Ahmad, Po-Han Lin, Qing Zhang, Bing Zeng, Qifeng Wang and Kamel Meguellati, Visible Light Induced C-H/N-H and C-X Bonds, Reactions 2023, 4(1), 189-230,
https://doi.org/10.3390/reactions4010012
[4] Adamu Yunusa Ugya, Kamel Meguellati, Phytotreatment of water contaminated with waste lubricatingoil using Pistia stratiotes, Chemistryand Ecology 2023, 39, 5, 423-437,
[6] Muhammad Siddique, Qifeng Wang, Kamel Meguellati, Cu-catalyzed selective Oxygenation of Aryl C‒H Bonds with O2and MnO2as Terminal Oxidants, Synlett,2025, 36(04):412-420,
DOI: 10.1055/a-1906-2916
[7] Muhammad Siddique Ahmad, Zahid Shafiq, Kamel Meguellati, Cu(I)-catalyzed cross dehydrogenative coupling (CDC) of ethers and substituted styrenes, Tetrahedron, 2022, 110, 132704,
[8] Muhammad Siddique Ahmad, Kamel Meguellati, Recent Advances in Metal Catalyzed C−H Functionalization with a Wide Range of Directing Groups, ChemistrySelect, 2022, 7, 7, e202103716,
https://doi.org/10.1002/slct.202103716
[9] Muhammad Siddique Ahmad, Kamel Meguellati, Qifeng Wang, Journal of Saudi Chemical Society, 2022, 3, 101483,
https://doi.org/10.1016/j.jscs.2022.101483
[10] Adamu Yunusa Ugya, Kamel Meguellati, Microalgae Biomass Modelling and Optimization for Sustainable Biotechnology – A Concise Review, Journal of Ecological Engineering 2022, 23,9, 2022,
DOI: https://doi.org/10.12911/22998993/150627
[11] Adamu Yunusa Ugya, Kamel Meguellati, Modelling Assisted Phytoremediation of Landfill Leachate Using Surface Flow Constructed Wetland Enhanced by Pistia stratiote and Salvinia molesta, J. Ecol. Eng. 2022; 23(5):226-236,
[12] Adamu Yunusa Ugya, Kamel Meguellati, Abdulkadir Dauda Aliyu, Abidina Abba & Makiyyu Abdullahi Musa, Microplastic stress induce bioresource production and response in microalgae: a concise review, Environmental Pollutants and Bioavailability, 2022, 34, 1, 51-60, https://doi.org/10.1080/26395940.2022.2033138
[13] Adamu Yunusa Ugya, Kamel Meguellati, Quantum technology a tool for sequencing of the ratio DSS/DNA modifications for the development of new DNA-binding proteins, Egyptian Journal of Basic and Applied Sciences, 2022, 9, 1, 308-323,
https://doi.org/10.1080/2314808X.2022.2082133
[14] Adamu Yunusa Ugya, Lin Pohan, Qifeng Wang, and Kamel Meguellati, Design of artificial cells: artificial biochemical systems, their thermodynamics and kinetics properties, Egyptian Journal of Basic and Applied Sciences, 2022, 9, 1, 393-412,
https://doi.org/10.1080/2314808X.2022.2104071
[15] Huasheng Tian, Runan Li, Po-Han Lin and Kamel Meguellati, Synthesis of a new solvent-responsive pillar[5]arene-based [1]rotaxane molecular machine, New J. Chem., 2020, 44, 10628-10632,
DOI: https://doi.org/10.1039/D0NJ01859G
[16] Muhammad Siddique Ahmad, Ruqiya Qasim, Qing Zhang, Bing Zeng, Jiamin Chen, Qifeng Wang and Kamel Meguellati, New J. Chem., 2023,47, 18173-18177,
https://doi.org/10.1039/D3NJ03726F
[17] Adamu Yunusa Ugya, Kamel Meguellati, Abdulkadir Dauda Aliyu, Abidina Abba, Makiyyu Abdullahi Musa, Microplastic stress induce bioresource production and response in microalgae: a concise review, Environmental Pollutants and Bioavailability 2022, 34, 1, 51-60,
DOI: 10.1080/26395940.2022.2033138
[18] Huasheng Tian, Ru-Nan Li, Po-Han Lin and Kamel Meguellati, Synthesis of A New Solvent-driven Pillar[5]arene-Based [1]Rotaxane Molecular Machine, New J. Chem., 2020, 44, 10628-10632.
https://doi.org/10.1039/D0NJ01859G,
[19] Runan Li, Qiong Jia, Xusheng Du, Rong Deng, Mengjun Wang, Chunyu Wang, Kamel
Meguellati, Controllable Fabrication of Novel Multi ‐Responsive Nano ‐Aggregates and Metallacycle Based on Bis‐Acylhydrazone Functionalized Pillar[5]arene, Asian Journal of Organic Chemistry 2020, 9, 4:549-552.
https://doi.org/10.1002/ajoc.202000003
[20] Rong Deng, Bai Ji, Hongliang Yu, Wei Bao, Zhuoqi Yang, Ying Yu, Yahan Cui, Yangyang Du, Meiyu Song, Shujun Liu, Kamel Meguellati & Fei Yan, Multifunctional Gold Nanoparticles Overcome MicroRNA Regulatory Network Mediated-Multidrug Resistant Leukemia, Scientific Reports 2019, 9:5348.
https://doi.org/10.1038/s41598-019-41866-y
[21] Huasheng Tian, Chunyu Wang, Haiying Li, Rong Deng, Runan Li, Kamel Meguellati, A New Cationic Functionalized Pillar[5]arene and Applications for Adsorption of Anionic Dyes, EurJoc 2019,17:2819-2823.
https://doi.org/10.1002/ejoc.201900256
[22] Ya-Han Cui, Rong Deng, Zheng Li, Xu-Sheng Du, Qiong Jia, Xing-Huo Wang, Chun-Yu Wang, Kamel Meguellati,* Pillar[5]arene pseudo [1]rotaxane-based redox-responsive supramolecular vesicles for controlled drug release, Mater. Chem. Front. 2019, 3:1427-1432.
https://doi.org/10.1039/C9QM00237E
[23] Mengjun Wang, Xusheng Du, Huasheng Tian, Qiong Jia, Rong Deng, Yahan Cui, Chunyu Wang, Kamel Meguellati, Chinese Chemical Letters 2019, 30, 2:345-348.
DOI: 10.1016/j.cclet.2018.10.014
[24] Xu-Sheng Du, Qiong Jia, Chun-Yu Wang, Kamel Meguellati and Ying-Wei Yang A pillar[5]arene with an amino-terminated arm stabilizes the formation of aliphatic hemiaminals and imines, Chem. Commun., 2019, 55, 5736-5739.
https://doi.org/10.1039/C9CC01947B
[25] Qiong Jia, Xusheng Du, Chunyu Wang, Kamel Meguellati, Chinese Chemical Letters 2019, 30,3:721-724.
https://doi.org/10.1016/j.cclet.2018.12.015
[26] Xu Wang, Jie Yang, Xiujuan Sun, Hongliang Yu, Fei Yan, Kamel Meguellati, Ziyong Cheng, Haiyuan Zhang and Ying-Wei Yang, Facile surface functionalization of upconversion nanoparticles with phosphoryl pillar[5]arenes for controlled cargo release and cell imaging, Chem. Commun., 2019, 55:5736-5739.
https://doi.org/10.1039/C9CC01947B
[27] Rong Deng, Shen N., Yang Y., Yu H., Xu S., Yang YW, Liu S, Kamel Meguellati, Yan Fei, Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy, Biomaterials 2018,167:80-90.
https://doi.org/10.1016/j.biomaterials.2018.03.013
[28] Huasheng Tian, Chunyu Wang, Kamel Meguellati, Synthesis and characterization of a new pillar[5]arene-based [1]rotaxane, Tetrahedron Letters 2018, 59, 37:3416-3422.
https://doi.org/10.1016/j.tetlet.2018.08.004
[29] Xu-Sheng Du, Chun-Yu Wang, Qiong Jia, Rong Deng, Hua-Sheng Tian, Hou-Yu Zhang, Kamel Meguellati, Pillar[5]arene-based [1]rotaxane: high-yield synthesis, characterization and application in Knoevenagel reaction, Chem. Commun. 2017, 53:5326-5329.
DOI: 10.1039/c7cc02364b
[30] CuhaWijay Sathiyajith, Rafik Rajjak Shaikh, Qian Han, Yue Zhang, Kamel Meguellati, Pillar[5]arene-based [1]rotaxane: high-yield synthesis, characterization and application in Knoevenagel reaction, Chem. Commun. 2017, 53:677-696.
https://doi.org/10.1039/C6CC08967D
[31] Li Xi, Rafik Rajjak Shaikh, Priya Roosevelt, Xusheng Du, Hongliang Yu, Dylan Novack, Kamel Meguellati, Mediterranean Journal of Chemistry 2017, 6(3):49-52.
http://dx.doi.org/10.13171/mjc62/01701171722-meguellati
[32] Sirinan Kulchat, Kamel Meguellati, Jean‐Marie Lehn, Organocatalyzed and Uncatalyzed C=C/C=C and C=C/C=N Exchange Processes between Knoevenagel and Imine Compounds in Dynamic Covalent Chemistry, Helvetica Chimica Acta 2014, 97, 9:1219-1236.
https://doi.org/10.1002/hlca.201400187
[33] Ali Fallah-Araghi, Kamel Meguellati, Jean-Christophe Baret, Abdeslam El Harrak, Thomas Mangeat, Martin Karplus, Sylvain Ladame, Carlos M. Marques, and Andrew D. Griffiths, Enhanced Chemical Synthesis at Soft Interfaces: A Universal Reaction-Adsorption Mechanism in Microcompartments, Phys. Rev. Lett. 2014, 112:028301.
https://doi.org/10.1103/PhysRevLett.112.028301
[34] Kamel Meguellati, Girish Koripelly and Sylvain Ladame,Single Nucleotide Polymorphism Detection Using a Biocompatible, Fluorogenic and DNA-Templated Reaction of Cyanine Dye Formation, J AnalytMolecul Tech 2013, 1, 1:5.
https://www.avensonline.org/fulltextarticles/jamt-2474-1914-01-0002.html,
[35] Kamel Meguellati, Ali Fallah-Araghi, Jean-Christophe Baret, Abdeslam El Harrak, Thomas Mangeat, Carlos M Marques, Andrew D Griffiths, Sylvain Ladame, Enhanced imine synthesis in water: from surfactant-mediated catalysis to host–guest mechanisms, Chem. Commun. 2013, 49, 96:11332-11334.
https://doi.org/10.1039/C3CC46461J
[36] Kamel Meguellati, Sylvain Ladame, Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity, Constitutional Dynamic Chemistry, Springer 2011 pp 291-314.
DOI: 10.1007/128_2011_277
https://link.springer.com/chapter/10.1007/128_2011_277
[37]Kamel Meguellati, Girish Koripelly, Sylvain Ladame,DNA-templated synthesis of trimethine cyanine dyes: a versatile fluorogenic reaction for sensing G-quadruplex formation, Angewandte Chemie 2010, 49, 15:2738-2742. https://doi.org/10.1002/anie.201000291
[38]Kamel Meguellati, Martin Spichty, and Sylvain Ladame, Synthesis, spectroscopic and DNA alkylating properties of malondialdehyde (MDA) bis-imine fluorescent adducts, Mol. BioSyst. 2010, 6:1694-1699.
https://doi.org/10.1039/C002157A
[39]Kamel Meguellati, Sylvain Ladame, and Martin Spichty, A conceptually improved TD-DFT approach for predicting the maximum absorption wavelength of cyanine dyes, Dyes and Pigments 2011, 90, 2:114–118.
DOI: f10.1016/j.dyepig.2010.12.001f
[40]Kamel Meguellati; Martin Spichty; Sylvain Ladame, Reversible Synthesis and Characterization of Dynamic Imino Analogues of Trimethine and Pentamethine Cyanine Dyes, Organic Letters 2009, 11, 5:1123-1126.
https://doi.org/10.1021/ol802913b
[41] Fabrice Ndayisenga, Po-Han Lin, Runan Li, Abdul Hameed, Yue Zhang, Kamel Meguellati, Site-specific modification of proteins by chemical/enzymatic strategies, Int. J. Biosci., 2020, 16, 3:12-50.
http://dx.doi.org/10.12692/ijb/16.3.12-50
[42] Yahan Cui, Rong Deng, Xiangshuai Li, Xinghuo Wang, Qiong Jia, Emilie Bertrand, Kamel Meguellati, Chinese Chemical Letters 2019, 30, 12:2291-2294.
DOI: 10.1016/j.cclet.2019.08.017
6.联系方式：
地址：广州市番禺区兴业大道东855号 点点手机版app药学院
邮箱: kamel2021@jnu.edu.cn
电话: 18210226905
办公室: 药学院大楼720
